DotNetNuke 4.6.2 was released today! You can get it from www.dotnetnuke.com
You can see what was fixed in 4.6.1 which was released last week with the link below. I believe, and this is unofficial, the 4.6.2 release contains a quick fix for ModuleSettingsBase
Download it now! I've already upgraded a few sites to 4.6.2 and will be upgrading more sites this week!